Table 6.
Risk of death according to age of the individuals (exposed compared to unexposed)
| Exposed, N=8,999 | Unexposed, N=24,118 | Crude HR | p-value | Adjusted HR | p-value | |
|---|---|---|---|---|---|---|
| Death in the overall population, n (%) | 636 (7.0) | 1,665 (6.9) | 0.93 (0.85–1.02) | 0.12 | 0.90 (0.81–1.00) | 0.05 |
| ≤70 years | 306 (4.1) | 923 (4.5) | 0.79 (0.69–0.90) | <0.001 | 0.76 (0.66–0.88) | <0.001 |
| >70 years | 330 (22.3) | 742 (20.6) | 1.06 (0.93–1.21) | 0.34 | 1.09 (0.93–1.26) | 0.28 |
| Death in those with newly developed cancer, n (%)a | 151 (30.6) | 464 (38.0) | 0.74 (0.61–0.89) | 0.001 | 0.78 (0.64–0.96) | 0.02 |
| ≤70 years | 91 (25.6) | 312 (35.3) | 0.64 (0.51–0.81) | <0.001 | 0.70 (0.55–0.91) | 0.007 |
| >70 years | 60 (43.2) | 152 (45.1) | 1.00 (0.74–1.34) | 0.98 | 0.98 (0.68–1.42) | 0.93 |
| Death in those without newly developed cancer, n (%)a | 485 (5.7) | 1,201 (5.2) | 1.00 (0.90–1.11) | 0.99 | 0.96 (0.86–1.08) | 0.53 |
| ≤70 years | 215 (3.0) | 611 (3.1) | 0.85 (0.72–0.99) | 0.04 | 0.81 (0.68–0.96) | 0.02 |
| >70 years | 270 (20.1) | 590 (18.0) | 1.09 (0.94–1.26) | 0.25 | 1.13 (0.96–1.33) | 0.14 |
Notes:
a
Excluding basal cell carcinoma. Models adjusted on age, sex, underlying condition, smoking status, past history of cancer, past history of diabetes, past history of hypertension, BMI, deprivation index, and number of NSAIDs, metformin, vitamin D, glucocorticoids, methotrexate, and azathioprine prescriptions.
Abbreviations: BMI, body mass index; HR, hazard ratio; NSAIDs, nonsteroidal antiinflammatory drugs.