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. 2017 Nov 9;12(11):e0187752. doi: 10.1371/journal.pone.0187752

Fig 7. IPA network analysis of the modified proteins in the aorta of insulin-treated diabetic relative to diabetes rats.

Fig 7

The top Toxicity and functions predicted by IPA related to the modified proteins are Cardiac Fibrosis, Hypertrophy, Necrosis/Cell Death, Oxidative Stress, Increased Cardiac Proliferation, Dilation, and Dysfunction. The main regulated proteins connected in this network are ACE, AGT, and TNF. B: Diseases and Biological Functions predicted by IPA related to the differentially expressed proteins in this comparative group. The main biological functions altered in this network are apoptosis, metabolism of hydrogen peroxide, and release of reactive oxygen species. The diseases related to these proteins are damage of blood vessel, and hypertrophy of thoracic aorta. The color intensity of the nodes reflects the expression of the proteins. Green nodes are downregulated proteins, red nodes are upregulated proteins, white nodes are IPA predicted proteins with non-consistent activation pattern, blue nodes are IPA predicted proteins to be inhibited, and orange nodes are IPA predicted proteins to be activated.