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. 2017 Nov 9;12(11):e0176181. doi: 10.1371/journal.pone.0176181

Fig 3. Sample level gene expression changes in MSI-H UCEC samples with a JAK1 frameshift.

Fig 3

(A) Heatmap of MSI-H, UCEC tumors (columns). Marker rows: 1) Samples with a JAK1 frameshift are denoted in green. 2) IFN Response, after JAK1 frameshift samples are ordered by IFN Response. 3) Log10 of JAK1 expression. 4) JAK1 frameshift (FS) MAF. Gene expression was scaled by Z scoring and the order of genes (rows) is determined by the signal to noise metric for GSEA analysis (t). Negative t indicated decreased expression in JAK1 frameshift samples. Only genes in the HALLMARK IFN GAMMA RESPONSE are shown. (B) Histogram of IFN Gamma Response in arbitrary units (AU). (C) Scatter plot of samples for JAK1 expression and IFN Gamma Response. Pearson’s r and associated P values are shown. (D) Scatter plot of samples for JAK1 expression and JAK1 FS MAF. Pearson’s r and associated P values are shown. (E) Scatter plot of JAK1 frameshift samples for JAK1 FS MAF and IFN Gamma Response. Pearson’s r and associated P value is shown.