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. 2017 Nov 9;12(11):e0187946. doi: 10.1371/journal.pone.0187946

Table 2. Association of education level with overall frailty and with its six components (Model 1) and change in association of education level with the five other frailty components after adjustment for the morbidities component (Model 2); stratified by age group among 26,014 persons of The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS).

Overall Frailty Morbidities ADL limitations IADL limitations Psychosocial health Health-related quality of life Self-rated health
B (95% CI) B (95% CI) B (95% CI) % B (95% CI) % B (95% CI) % B (95% CI) % B (95% CI) %
Model 1
Age 55–69 years
 Secondary education 0.016** 0.019*** 0.007 0.005 0.016 0.020* 0.028**
(0.005–0.026) (0.008–0.030) (-0.008–0.022) (-0.013–0.023) (-0.003–0.036) (0.003–0.038) (0.011–0.046)
 ≤ Primary education 0.047*** 0.052*** 0.013 0.034** 0.074*** 0.056*** 0.064***
(0.035–0.059) (0.039–0.064) (-0.005–0.030) (0.013–0.055) (0.051–0.096) (0.036–0.076) (0.044–0.085)
Age 70–79 years
 Secondary education 0.007* 0.008** -0.002 0.011* 0.006 0.005 0.016***
(0.001–0.013) (0.002–0.014) (-0.010–0.007) (0.000–0.021) (-0.003–0.015) (-0.004–0.014) (0.007–0.025)
 ≤ Primary education 0.027*** 0.022*** 0.010* 0.039*** 0.034*** 0.029*** 0.043***
(0.021–0.033) (0.015–0.028) (0.000–0.019) (0.028–0.051) (0.024–0.044) (0.019–0.038) (0.033–0.053)
Age ≥ 80 years
 Secondary education 0.015*** 0.012** 0.001 0.019* 0.022*** 0.018** 0.014*
(0.006–0.024) (0.003–0.021) (-0.014–0.016) (0.001–0.036) (0.009–0.035) (0.005–0.031) (0.001–0.026)
 ≤ Primary education 0.026*** 0.019*** 0.012 0.044*** 0.026*** 0.033*** 0.022***
(0.017–0.036) (0.009–0.028) (-0.003–0.028) (0.026–0.063) (0.012–0.040) (0.019–0.046) (0.007–0.035)
Model 2
Age 55–69 years
 Secondary education NA NA 0.001 NA -0.003 NA 0.003 NA 0.009 55% 0.017* 39%
(-0.014–0.16) (-0.021–0.014) (-0.015–0.022) (-0.007–0.025) (0.001–0.034)
 ≤ Primary education NA NA -0.003 NA 0.014 59% 0.040*** 46% 0.026** 54% 0.036*** 44%
(-0.021–0.014) (-0.007–0.034) (0.019–0.062) (0.007–0.044) (0.016–0.056)
Age 70–79 years
 Secondary education NA NA -0.005 NA 0.006 45% 0.002 NA 0.001 NA 0.013** 9%
(-0.014–0.004) (-0.004–0.016) (-0.007–0.011) (-0.007–0.008) (0.004–0.021)
 ≤ Primary education NA NA 0.002 80% 0.028*** 28% 0.024*** 29% 0.016*** 45% 0.032*** 26%
(-0.008–0.011) (0.017–0.039) (0.014–0.034) (0.007–0.025) (0.023–0.042)
Age ≥ 80 years
 Secondary education NA NA -0.005 NA 0.011 42% 0.016** 27% 0.010 44% 0.008 43%
(-0.020–0.010) (-0.006–0.028) (0.003–0.028) (-0.002–0.022) (-0.004–0.020)
 ≤ Primary education NA NA 0.003 NA 0.032*** 27% 0.017** 35% 0.021*** 36% 0.013* 41%
(-0.012–0.019) (0.015–0.050) (0.003–0.030) (0.008–0.033) (0.001–0.025)

Values are derived from multilevel multivariable linear regression, tertiary education is the reference group. Model 1 is adjusted for confounders: age, sex, and living arrangement (alone/not alone). Model 2 is additionally adjusted for morbidities.

* p<0.05;

** p<0.01;

*** p<0.001.

% represents the % change in effect estimates relative to model 1 after adjustment for morbidities; this was calculated by: 100x ((Bmodel1-Bmodel2)/Bmodel1). B = effect estimate; CI = confidence interval; (I)ADL = (instrumental) activities of daily living