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. 2017 Oct 30;13(10):e1006713. doi: 10.1371/journal.ppat.1006713

Fig 2. Impact of ESCRT-II knockdown on activation of the IFN-β promoter by ectopic expression of various signaling proteins in TLR3 and RIG-I pathways.

Fig 2

(A) IFN-β promoter activity following ectopic expression of control vector, TRIF, TBK1, IKKε or IRF3-5D in PH5CH8 cells that had been transfected with the indicated siRNAs. (B) IFN-β promoter activity following ectopic expression of control vector, RIG-I CARD (RIG-I-N), MDA5, or MAVS in PH5CH8 cells that had been transfected with the indicated siRNAs.“*”, “**”, and “***” denote statistical differences exist as compared with control siRNA-transfected cells with a P-value of < 0.05, < 0.01 and <0.001, respectively.