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. 2017 Oct 30;13(10):e1005831. doi: 10.1371/journal.pcbi.1005831

Fig 1. Snapshots of simulated system with a lipid composition of bmp:chol:sm:dopg:popc = 20:10:0:0:70 (System 5).

Fig 1

A) A typical starting configuration for npc2 in the water phase, above the membrane. B) Final configuration after a simulation of 400 ns in a case, where the cholesterol-binding pocket faces the membrane (Prone mode). C) Final configuration of a simulation, where the cholesterol-binding pocket faces the water phase (Supine mode). The residue G61 residing at the opening of the binding pocket is highlighted. Color code for lipids: bmp (violet), chol (green), popc (light brown). For clarity’s sake, water is not shown.