Table 2.
Volumetric changes associated with the menstrual cycle
| Menstrual cycle—volumetric changes | ||
|---|---|---|
|
| ||
| Study | Analysis | Regions |
| Follicular > luteal | ||
| Protopopescu et al. (2008a)a | VBM | L lingual g., R hippocampus/parahippocampal g., L mid frontal g. |
| ROI | R hippocampus | |
| Pletzer et al. (2010) | VBM | R fusiform/parahippocampal g. |
| De Bondt et al. (2013a) | VBM | R mid frontal g., b/l BA 6, L cingulate g., R ACC, L mid temporal g., L insula |
| Lisofsky et al. (2015b) | VBM | L hippocampus/parahippocampal g., b/l cerebellum |
| Luteal > follicular | ||
| Grant et al. 1988/Teasdale et al. (1988) | ROI | CSF volume |
| Protopopescu et al. (2008a)a | VBM | L sup parietal lobule, R dorsal basal ganglia, R medial frontal g./ACC, R thalamus |
| ROI | R dorsal basal ganglia | |
| Pletzer et al. (2010) | VBM | None |
| Ossewaarde et al. (2013) | ROI | L amygdala |
| De Bondt et al. (2013a) | VBM | R sup temporal g. |
| Lisofsky et al. (2015b) | VBM | R cerebellum |
| Follicular = luteal | ||
| Pletzer et al. (2010) | VBM | Total GM |
| Grams et al. (2010) | ROI | Pituitary gland |
| Hagemann et al. (2011) | Volumetry | Total GM, total WM, total CSF |
| Peri-ovulatory > menstrual | ||
| Hagemann et al. (2011) | Volumetry | Total GM |
| Tu et al. (2013)a | ROI |
(PD patients): L secondary somatosensory cortex, L ACC/dPCC (Healthy controls): none |
| Lisofsky et al. (2015b) | VBM | R cerebellum, R insula, L inf parietal lobe, b/l post hippocampib, b/l thalamib |
| Menstrual > peri-ovulatory | ||
| Hagemann et al. (2011) | Volumetry | CSF volume |
| Tu et al. (2013)a | ROI |
(PD patients): L medial OFC, L precentral g., L inf temporal g., R hypothalamus (Healthy controls): none |
| Lisofsky et al. (2015b) | VBM | R inf parietal lobe |
| Peri-ovulatory = menstrual | ||
| Tu et al. (2013)a | VBM | Total GM |
| Grams et al. (2010) | ROI | Pituitary Gland |
| Hagemann et al. (2011) | Volumetry | Total WM |
| Primary dysmenorrhea patients > healthy controls | ||
| Tu et al. (2010)a | ROI | R post hippocampus/parahippocampal g., ACC/dPCC, periaqueductal grey, hypothalamus, L ventral precuneus, L sup/mid temporal g., R cerebellar tonsil |
| Healthy controls > primary dysmenorrhea patients | ||
| Tu et al. (2010)a | ROI | R medial frontal g./PFC, R central and ventral precuneus, b/l secondary somatosensory cortices, insula, R culmen, L cerebellar tonsil |
| Primary dysmenorrhea patients = healthy controls | ||
| Tu et al. (2010)a | VBM | Total GM |
ACC anterior cingulate cortex, CSF cerebrospinal fluid, dPCC dorsal posterior cingulate cortex, GM grey matter, g gyrus, inf inferior, L left, med medial, mid middle, NA not applicable, NR not reported, OCP oral contraceptive pills, OFC orbitofrontal cortex, PFC prefrontal cortex, post posterior, R right, ROI region of interest, sup superior, VBM voxel-based morphometry
Includes or focuses on patients with menstrual cycle related symptoms (PMDD or PD)
These two regions were found in a comparison of the early follicular (menstrual) vs. late follicular phases, but the late follicular phase as defined by Lisofsky et al. (2015b) (days 10–13) shows considerable overlap with our designation of the peri-ovulatory phase (days 12–16) and thus is grouped with the other menstrual vs. peri-ovulatory results for simplicity