Table 3.

Volumetric changes associated with hormonal contraceptive use

Hormonal contraceptive use—volumetric changes
Study	Analysis	Regions
Menstrual cycling women > OCP users
Pletzer et al. (2010)	VBM	None
Grams et al. (2010)	ROI	Pituitary volume
De Bondt et al. (2013a)	VBM	L Fusiform gyrus
Pletzer et al. (2015)	ROI	(vs. androgenic OCP users): b/l mid frontal g., L sup frontal g.
OCP users > menstrual cycling women
Pletzer et al. (2010)	VBM	B/l PFC, b/l ACC, b/l pre/post-central g., b/l SMA, R fusiform g., R parahippocampal g., R lingual g., R sup/inf temporal g., b/l cerebellum
De Bondt et al. (2013a)	VBM	R BA 6, R sup frontal g., b/l fusiform g., R cingulum
Pletzer et al. (2015)	ROI	(vs. anti-androgenic OCP users): b/l fusiform g., b/l fusiform face areas, b/l parahippocampal place area, cerebellum
Menstrual cycling women = OCP users
Grant et al. 1988/Teasdale (1988)	ROI	Total CSF
Pletzer et al. (2010)	VBM	Total GM
De Bondt et al. (2013a)	VBM	Total GM
Pletzer et al. (2015)	VBM	Total GM
Active pill > inactive pill
De Bondt et al. (2013a)	VBM	L ACC, L insula
Inactive pill > active pill
De Bondt et al. (2013a)	VBM	L BA 6, R post-central g., L caudate (ACC)
Pletzer et al. (2015)	ROI	L fusiform g., b/l fusiform face areas, L parahippocampal place area, R cerebellum

ACC anterior cingulate cortex, b/l bilateral, CSF cerebrospinal fluid, dPCC dorsal posterior cingulate cortex, g gyrus, GM grey matter, inf inferior, L left, mid middle, OCP oral contraceptive pills, PFC prefrontal cortex, post posterior, R right, ROI region of interest, sup superior, SMA supplementary motor area, VBM voxel-based morphometry