Fig. 4.

IL2Rγ-chain cytokines affect the ability of adoptively transferred Th17 cells to control tumor growth. a Depletion of IL-2 and IL-7 decreases efficacy of Th17 adoptive transfer. B6 mice bearing established B16 melanomas received adoptive transfer of 5 × 10⁵ TRP-1 Th17 cells. The indicated IL2Rγ-chain cytokines were then depleted from the mice, and tumor area was measured three times per week. Each line represents one mouse. b Survival curves for deaths due to any cause (top) or only deaths attributable to tumor burden (tumor area > 400 mm²) (bottom). Survival data was pooled from two independent experiments with a total of 14–16 mice or 8–12 mice per group for all cause and tumor-specific mortality respectively, *p < .05, ** p < .01, *** p < .001 by log-rank test