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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Stroke. 2017 Oct 10;48(11):3108–3116. doi: 10.1161/STROKEAHA.117.017681

Figure 6.

Figure 6

CRTC3 in vivo knock-down with intraventricle siRNA abolished the attenuation intranasal Bosutinib on brain edema, neurological deficiency and neuroinflammation 24h after ICH. Statistical analysis of brain water content (A) Garcia test (B) were performed. (C) Quantitative detection of CREB that binds to a DNA consensus sequence in a colorimetric assay. Levels of CREB expressed as average absorbance +/− SD of six wells. (D) Representative Western Blot bands and quantification of NFkB-p65 in indicated groups. Relative densities have been normalized against the sham group. n=6, *P<0.05 vs sham; #P<0.05 vs ICH+Vehicle; and &P<0.05 vs ICH+scramble siRNA.