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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Am J Med Genet A. 2017 Sep 21;173(11):2861–2872. doi: 10.1002/ajmg.a.38464

Table II.

Down syndrome (DS), DS sibling (DSsib), and unrelated euploid (EU) facial variance results.

Samples Compared Confidence interval results for local linear distance (LD) variance differences
Percentage of
significantly
different LDs		 Number of LDS with significantly
larger variances		 Number of LDS with significantly
smaller variances
DS compared to DSsib 27/190 (14%) 23/190 (Avg. 84% variance increase in DS; Range 58–125% variance increase in DS) 4/190 (Avg. 40% variance increase in EU; Range 33–48% variance increase in EU)
DS compared to EU 34/190 (18%) 34/190 (Avg. 74% variance increase in DS; Range 14–130% variance increase in DS) 0/190
DSsib compared to EU 10/190 (5%) 5/190 (Average 65% variance increase in DSsib; Range 60–70% variance increase in DSsib) 5/190 (Avg. 41% variance increase in EU; Range 34–50% variance increase in EU)