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. Author manuscript; available in PMC: 2018 Mar 11.
Published in final edited form as: Nat Immunol. 2017 Sep 11;18(11):1238–1248. doi: 10.1038/ni.3835

Fig. 5. Connecting cofactor interaction and transcriptional activity.

Fig. 5

(a) Pearson correlation between FoxP3 mutants’ binding to RELA or YY1 (Y-axis) and their ability to induce expression of FoxP3-induced (Ctla4, Lrrc32) or –repressed (Pde3b) targets (X-axis, per Fig. 2b). (b) As in a, correlation between the mutants’ ability to activate each FoxP3-induced target and the ability to bind each cofactor; the heatmap shows the coefficient from linear model including DNA-binding as a covariate (hierarchically clustered, rows and columns). (c) Representative traces of ELF1 and ETS1 and FoxP3 binding at representative FoxP3-induced and –repressed signature loci. (d) Density of chromatin marks for ELF1 and ETS1 ChIPseq in a 10 kb window around FoxP3 binding sites for Treg -up or-down signature loci (data from 26).