. 2017 Nov 1;6:e29510. doi: 10.7554/eLife.29510

Table 1. Mitf alleles used in this study.

The effect on gene expression as well as the organismal phenotype associated with each allele is shown. All mutants are on C57Bl/6J background.

					Phenotype
Allele	Symbol	Mode of induction	Lesion	Effect	Heterozygote	Homozygote
micropthalmia	Mitf^mi	X-irradiation	3 bp deletion in basic domain	Affects Mitf DNA binding affinity	Iris pigment less than in wild type; spots on belly, head and tail	White coat, eyes small and red; deficiency of mast cells, basophils, and natural killer cells; spinal ganglia, adrenal medulla, and dermis smaller than normal; incisors fail to erupt, osteopetrosis; inner ear defects
White	Mitf^Mi-wh	Spontaneous or X-irradiation	I212N	Affects Mitf DNA binding affinity	Coat color lighter than dilute (d/d); eyes dark ruby; spots on feet, tail and belly; inner ear defects	White coat; eyes small and slightly pigmented; spinal ganglia, adrenal medulla, and dermis smaller than normal; inner ear defects; reduced fertility
VGA-9	Mitf^mi-vga9	Transgene insertion	Transgene insertion and 882 bp deletion	Loss-of-function	Normal	White coat, eyes red and small; inner ear defects
enu-22(398)	Mitf^{mi-enu22(398)}	Ethylnitroso-urea	C205T, Q26STOP in exon 2A,	Affects splicing	Normal	Normal eyes, white belly and large unpigmented spots in coat

This table was modified from Steingrimsson et al. (2004). Information for the allele enu-22(398) comes from Bauer et al. (2009).