Author response image 1. Quantification of reference model perturbation on LocScale maps.

(A) Residue-averaged real space correlation (RSCC) for TRPV1 residues 430-449 computed between the original PDB (WT) and LocScale maps obtained with scaling using a WT, F436A, V440W or poly-Ala reference map. (B) Residue-averaged real space correlation (RSCC) for TRPV1 residues 430-449 computed between the original PDB (WT) and the simulated reference maps obtained from WT, F436A, V440W or poly-Ala coordinate models.