Figure 1.

Molecular structure of carfilzomib, bortezomib, and ixazomib citrate. (A): Chemical name of the active substance carfilzomib: (2S)‐N‐((S)‐1‐((S)‐4‐methyl‐1‐((R)‐2‐methyloxiran‐2‐yl)‐1‐oxopentan‐2‐ylcarbamoyl)‐2‐phenylethyl)‐2‐((S)‐2‐(2‐morpholinoacetamido)‐4‐phenylbutanamido)‐4‐methylpentanamide. (B): Chemical name of the active substance bortezomib: {(1R)‐3‐methyl‐1‐[(2S)‐3‐phenyl‐2‐(pyrazin‐carboxamido)=propanamido]butyl}boronic acid. (C): Chemical name of the active substance ixazomib citrate: 2,2′‐{2‐[(1R)‐1‐({[(2,5 dichlorobenzoyl)amino]acetyl}amino)‐3‐methylbutyl]‐5‐oxo‐1,3,2‐ dioxaborolane‐4,4‐diyl}diacetic acid.