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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Biochemistry. 2017 Jun 16;56(26):3369–3379. doi: 10.1021/acs.biochem.7b00403

Figure 6.

Figure 6

Proposed mechanism for Mn/Fe R2lox assembly. Modeled rate constants from this global kinetic model are inherently distinct from apparent rate constants obtained from fitting experimental data to simple exponential functions (Table 1). Product KIE obtained from isotope exchange EPR data. (Inset) Optical spectra obtained from SVD analysis (top) and representative EPR spectra (middle) of each intermediate as well as product. (Bottom) Relative concentrations obtained from experimental data overlaid with model simulations.