Figure 1.

Immunogenomic approaches to infer the role of disease variants. Variants associated to immune diseases can be functionally annotated using immunological or a genomic approaches. Immunological approaches include the (a) systemic analysis of immune function, such as measuring cell type ratios and cytokine levels, and (b) cellular analysis, such as proliferation assays of a specific cell type in response to a stimulus, the lineage specification markers or protein expression levels. Genomic assays, include (c) gene expression and (d) epigenetics; transcription factor binding sites, chromatin accessibility, histone modifications and DNA methylation.