Table 1.
Effect of neurofilament light (NF‐L) ‐specific antibodies in myelin oligodendrocyte glycoprotein 35–55 (MOG35–55)‐induced experimental autoimmune encephalomyelitis (EAE)
| Treatment | No. EAE | Mean group scorea | Mean EAE scoreb | Mean day of onsetc | AUCd** |
|---|---|---|---|---|---|
| MOG35–55 | 9/11 | 3·3 ± 1·6 | 4·0 ± 0·0 | 14·1 ± 2·1 | 46·4 ± 1·1 |
| MOG35–55 + NF‐L 10H9 | 6/6 | 4·0 ± 0·0 | 4·0 ± 0·0 | 12·3 ± 1·0 | 63·2 ± 1·4** |
a
Mean ± SEM of maximum clinical score of EAE from all mice in the group.
b
Mean ± SEM of maximum clinical score from mice exhibiting EAE within a group.
c
Mean ± SD of day of onset of clinical disease.
d
AUC ± SD Cumulative scores are expressed as area under the curve (AUC). Cumulative clinical scores were calculated as the sum of all the daily scores over the course of EAE, **P = 0·01.