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. 2017 Aug 23;152(4):628–637. doi: 10.1111/imm.12804

Figure 1.

Figure 1

Proliferation of CD4+ T cells induced by thalidomide (TM), dexamethasone (DX), or TM/DX combinatorial treatment. Naive T (Tnaives) cells, which were labelled with CFSE, were incubated with anti‐CD3 and anti‐CD28 antibodies for 72 hr, and analysed by flow cytometry. TM/DX combinatorial treatment down‐regulated the proliferation of CD4+ T cells from Tnaive cells more than DX alone. (a) Histogram plots of CFSE intensities. (b) Ratios of CD4+ CFSElo T cells. The numbers on the histogram indicate percentages of proliferating cells among total T cells. The results shown are representative plots selected from five independent experiments (% of non‐treated controls, n = 5). *P < 0·05, **P < 0·01, and ***P < 0·001, compared with untreated controls; ## P < 0·01 and ### P < 0·001 compared with 0·1 nm DX treatment; and ††† P < 0·001 compared with 1 nm DX treatment.