Figure 8. Temporal dynamics of different sub-populations with multiple driver mutations.

Radial mutation network with logistic growth equations. Each plot corresponds to a single step in carcinogenesis and plots the subpopulations at different instability levels. m = 3, n = 3, d₀ = 10⁻⁴, d₁ = 10⁻⁴, d₀ = 10⁻³, d₂ = 10⁻², d₃ = 10⁻¹, p₀ = 10⁻⁷, p₁ = 10⁻⁵, p₂ = 10^−3.5, p₃ = 10⁻², $K_{x_i^0}={10}^5$, $K_{x_i^1}={10}^7$, $K_{x_i^2}={10}^{12}$, $K_{x_i^3}={10}^{15}$, a₀ = 1, a₁ = 1.05, a₂ = 1.1, a₃ = 1.15, a₄ = 1.2.