Table 1.

Typical patterns for evolution of genetic instability and evolution of individual clonal waves. Results with ^□ are observed for models with both one and multiple driver mutations. Results with ^◇ are observed only for models with multiple driver mutations.

Typical patterns for evolution of individual clonal waves	Typical patterns for evolution of genetic instability
□1. Stable throughout growth Results from low mutation rates and high death rates Instability is a “passenger” phenomenon	□1. Instability does not evolve Observed when the death rates are large and mutation rates are low
◇2. Originates from unstable cells then stabilizes Results from high mutation rates and moderate death rates Instability is a causal event	□2. Instability is generated but gives way to more stable clones Observed when the death rates and mutation rates are in balance
◇3. Originates from unstable cells and remains unstable Results from high mutation rates and low death rates Instability is a causal event	□3. Instability evolves and comes to dominate the system Observed when the death rates are low and mutation rates are large