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. 2017 Nov 9;7:15134. doi: 10.1038/s41598-017-15420-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HFD induces immune and inflammatory genes associated with systemic inflammation, regardless of physical activity. (A) Scatter plot of 344 differentially expressed gene following 9 days of HFD, with or without resistance exercise (Sed-HFD and Ex-HFD intersection). Gene ontology analysis of the 344 genes that were either up-regulated (B) or down-regulated (C) in both the Sed-HFD and Ex-HFD groups. FDR < 0.1 is shown by the dotted line. Plasma profiles of free fatty acids (FFA; D), interleukin 6 (IL-6; E) and TNF-α (F) throughout the intervention period. ^#p < 0.002 for the effect of time; ^$p < 0.02 for the effect of exercise.