Table 2.
Selected genes associated with mitochondrial function and localization, metabolic enzymes, and immune regulation differentially regulated by HFD and preserved by concomitant resistance exercise.
| Ensembl ID | Gene | Description | logFC | P value | FDR |
|---|---|---|---|---|---|
| ENSG00000124107 | SLPI | secretory leukocyte peptidase inhibitor | 2,82 | 7,17E-09 | 7,28E-06 |
| ENSG00000138193 | PLCE1 | phospholipase C epsilon 1 | 0,94 | 2,22E-05 | 4,80E-03 |
| ENSG00000014641 | MDH1 | malate dehydrogenase 1 | −0,79 | 3,68E-05 | 7,17E-03 |
| ENSG00000134070 | IRAK2 | interleukin 1 receptor associated kinase 2 | 1,01 | 5,31E-05 | 8,94E-03 |
| ENSG00000176046 | NUPR1 | nuclear protein 1, transcriptional regulator | 0,76 | 8,99E-05 | 1,29E-02 |
| ENSG00000154518 | ATP5G3 | ATP synthase, H + transporting, mitochondrial Fo complex subunit C3 (subunit 9) | −0,74 | 1,07E-04 | 1,46E-02 |
| ENSG00000112715 | VEGFA | vascular endothelial growth factor A | −0,73 | 1,47E-04 | 1,88E-02 |
| ENSG00000087586 | AURKA | aurora kinase A | −1,14 | 1,56E-04 | 1,95E-02 |
| ENSG00000110955 | ATP5B | ATP synthase, H + transporting, mitochondrial F1 complex, beta polypeptide | −0,71 | 2,88E-04 | 3,13E-02 |
| ENSG00000159423 | ALDH4A1 | aldehyde dehydrogenase 4 family member A1 | −0,68 | 5,48E-04 | 4,75E-02 |
| ENSG00000263232 | ATP5A1P3 | ATP synthase, H + transporting, mitochondrial F1 complex, alpha subunit 1 pseudogene 3 | −0,71 | 6,70E-04 | 5,32E-02 |
| ENSG00000132313 | MRPL35 | mitochondrial ribosomal protein L35 | −0,70 | 7,28E-04 | 5,63E-02 |
| ENSG00000111241 | FGF6 | fibroblast growth factor 6 | −1,05 | 8,14E-04 | 6,18E-02 |
| ENSG00000169692 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | 0,73 | 8,36E-04 | 6,18E-02 |
| ENSG00000176340 | COX8 A | cytochrome c oxidase subunit VIIIA (ubiquitous) | −0,63 | 9,09E-04 | 6,48E-02 |
| ENSG00000166343 | MSS51 | MSS51 mitochondrial translational activator | −0,71 | 1,02E-03 | 7,01E-02 |
| ENSG00000184076 | UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | −0,61 | 1,23E-03 | 7,98E-02 |
| ENSG00000244482 | LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 2,51 | 1,43E-03 | 8,74E-02 |
| ENSG00000260318 | COX6CP1 | cytochrome c oxidase subunit VIc pseudogene 1 | −1,05 | 1,72E-03 | 9,85E-02 |
| ENSG00000120992 | LYPLA1 | lysophospholipase I | −0,90 | 1,72E-03 | 9,85E-02 |