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. 2017 Nov 9;7:15199. doi: 10.1038/s41598-017-15436-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Resistance acquisition assay of E. coli in the presence of D-Ctl compared to ampicillin and cefotaxime. The E. coli wild-type strain was cultured in the presence of ½ MIC of the antibacterial agent for 24 days. The fold change in MIC was evaluated at the indicated days.