Table 1.
Antibacterial activity of D-Ctl compared to L-Ctl.
| Pathogen | Gram | Respiratory type | MIC (peptide) | Antibiotic of reference | ||
|---|---|---|---|---|---|---|
| L-Ctl (µg/mL) | D-Ctl (µg/mL) | Name | (µg/mL) | |||
| Escherichia coli (ATCC 25922) | − | Facultative anaerobe | 75 | 8.0 | Ampicillin | 7.0 |
| Kanamycin | 21 | |||||
| Escherichia coli (MDR) (K-12) | − | Facultative anaerobe | 150 | 8.4 | Cefotaxime | 0.1 |
| Fusobacterium nucleatum (ATCC 49256) | − | Obligate anaerobe | 125 | 22 | Amoxicillin | 0.6 |
| Prevotella intermedia (ATCC 49046) | − | Obligate anaerobe | 149 | 10 | Amoxicillin | 0.5 |
| Parvimonas micra (ATCC 33270) | + | Obligate anaerobe | 120 | 23 | Amoxicillin | 0.5 |
| Staphylococcus aureus (MSSA) (ATCC 25923) | + | Facultative anaerobe | 40* | 24 | Methicillin | 1.2 |
| Staphylococcus aureus (MRSA) (S1) | + | Facultative anaerobe | 37* | 18 | Vancomycin | 0.8 |
The percentage of growth inhibition of the indicated pathogens in the presence of different concentrations of D-Ctl or L-Ctl was determined by broth microdilution assays. Each MIC, defined as the lowest concentration of a drug able to inhibit 100% of a bacterial inoculum, was determined using a modified Gompertz function. Experiments were performed with biological replicates. *Values obtained from Aslam et al.18.