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. 2017 Nov 9;7:15137. doi: 10.1038/s41598-017-15085-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lower zinc in the diets of the zinc-deficient mice reduced both short-term and long-term zinc stores. At GD18.5, a reduction in circulating zinc levels (a) as well as liver metallothionein (b) was observed in the zinc-deficient dams. Placental tissue zinc however remained similar between the two diet groups (c) and there was a trend for an increase in zinc content of fetuses from zinc-deficient dams (d). Data are median and interquartile range (n = 10 zinc-replete and 7 zinc-deficient [a & b] and n = 19 zinc-replete and 13 zinc-deficient [c & d]). Statistical significance was determined using Mann-Whitney Test on data based on an average litter size of 7.00. *P < 0.05, ^# P = 0.08.