Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 9;7:15137. doi: 10.1038/s41598-017-15085-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Maternal zinc deficiency during pregnancy resulted in changes to the placental architecture likely to affect fetal growth. Despite no significant different in the labyrinth zone mid-sagittal cross sectional area (a), labyrinth zone weight was reduced in the zinc-deficient placentas at GD18.5 (b). Double labelling immunohistochemistry was used to identify the fetal capillaries (FC), trophoblasts (TB) and maternal blood space (MBS) within the labyrinth zone (c). Analysis revealed decreases in the trophoblast volume (d) as well as trophoblast barrier thickness (e) in the placentas from zinc-deficient dams. An increase in fetal capillary volume density (f) and surface volume (g) was also found. Data are median and interquartile range (n = 23 and 21 placentas from 12 zinc-replete and 11 zinc-deficient dams, respectively). Statistical significance was determined using Mann-Whitney Test on data based on an average litter size of 7.00. *P < 0.05, **P < 0.01. GTB: giant trophoblast cells.