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. 2017 Nov 9;7:15194. doi: 10.1038/s41598-017-15209-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of Smed-AChE activity in planarian homogenates. Evaluation of Smed-AChE inhibition by insecticides and the associated enzymatically-generated degradation products in planarian homogenates. Blue and red bars represent the inhibition of Smed-AChE by insecticides and their degradation products respectively for paraoxon-ethyl (a), parathion-ethyl (b), diazinon (c) and fenitrothion (d). The values represent the mean ± SD (standard deviation) of three replicates. Black stars (*) indicate a significant difference between insecticide and degradation product for a given concentration (one star to indicate p < 0.05; two stars to indicate p < 0.005; three stars to indicate p < 0.0005 according to Student’s t-test).