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. 2017 Nov 9;7:15155. doi: 10.1038/s41598-017-15508-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dams with mammary gland disruption of Tph1 or Lrp5 during lactation have altered serum serotonin concentrations, but not altered tryptophan concentrations. Control dams or dams with a mammary-specific disruption of Tph1 or Lrp5 during lactation were euthanized on d10 of their second lactation. Shown are the effects of genetic disruption on serum (A) serotonin (n = 16 for Control, n = 10 for WAP-Cre × Lrp5 ^FL/FL, n = 10 for WAP-Cre × Tph1 ^FL/FL) and (B) tryptophan levels in the circulation (n = 15 for Control, n = 8 for WAP-Cre × Lrp5 ^FL/FL, n = 9 for WAP-Cre × Tph1 ^FL/FL). Values are means ± SEMs. Bars with same letter are not significantly different from one another. WAP-Cre × Lrp5 ^FL/FL, mammary- and lactation-specific disruption of Lrp5; WAP-Cre × Tph1 ^FL/FL, mammary- and lactation-specific disruption of Tph1.