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. 2017 Nov 9;7:15178. doi: 10.1038/s41598-017-15388-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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isomiR profile of miRNAs expressed in primary human chondrocytes. (A) Overall contribution of the canonical and seven different kinds of isomiR sequences to the total expressed repertoire of miRNAs. (B,C) isomiR expression of individual 20 top-ranked miRNAs. B shows the expression of isomiRs of individual miRNAs as percentage of total expression of all miRNAs. C shows the expression of different isomiRs of individual miRNAs as percentage of individual total. (D) Number of modifications in ten most modified miRNAs with ≥100 read counts.