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. 2017 Nov 9;7:15173. doi: 10.1038/s41598-017-15634-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HPV+ OPSCC has increased ANO1 expression relative to normal tissue and increased DNA methylation at positively correlated CpG islands. We studied HPV+ OPSCC compared to normal tissue. (A) HPV+ OPSCC has increased expression of ANO1 relative to normal tissue. Samples with DNA methylation at (B) the DRE or (C) exon 2 CpG island had increased expression of ANO1 compared to those that were unmethylated. HPV+ samples had (D) significantly increased DNA methylation at the DRE, (E) no difference at the CpG island, and (F) significantly increased DNA methylation at the exon 2 CpG island. Data presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.