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. 2017 Nov 9;7:15173. doi: 10.1038/s41598-017-15634-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EpiTYPER of HPV+ and HPV− tumor samples validates hypermethylation of positively correlated CpG islands in HPV− tumors. MALDI-TOF mass spectrometry was used to study DNA methylation in HPV− (n = 12) and HPV+ (n = 11) tumor samples. (A) Representative Epigram from individual HPV− and HPV+ tumors indicating position of CpG’s within PCR transcript. HPV− tumors had (B) a trend for hypermethylation of the DRE, (C) no change at the canonical CpG island, and (D) significant hypermethylation of the exon 2 CpG island. Data presented as mean ± SEM. *p < 0.05.