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. 2017 Nov 9;7:15173. doi: 10.1038/s41598-017-15634-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

DNA methylation at both positively and negatively correlated CpGs is associated with patient survival. Kaplan-Meier curves were used to assess survival of patients with HNSCC. Patients had significantly worse overall survival with (A) increased DNA methylation at the positively correlated CpG cg200232120, (B) decreased DNA methylation at the negatively correlated CpG cg18141744, (C) but no change in survival at the positively correlated CpG cg24891434. Low versus high was defined as below or above the median, respectively, of all samples studied. HR = Hazard Ratio, CI = 95% Confidence Interval.