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. 2017 Nov 9;8:1384. doi: 10.1038/s41467-017-01740-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Autotoxins are oenocyte-derived cuticular lipids. a, b Survival curves for LOW responder males showing that hexane extracts the autotoxin activity from preconditioned (PC) vials a or from adult cuticle b. c Autotoxin activity is not detectable in vials preconditioned with STD male donors overexpressing TSC1 + 2 in oenocytes (PromE ^TS > TSC), unlike control (w > TSC) or non-preconditioned vials (empty). d Dorsal oenocytes from 1 week STD males of a control genotype (PromE ^TS > mGFP), TSC1 + 2 overexpression (PromE ^TS > ;mGFP, TSC), Cyp4g1 RNAi (PromE ^TS > mGFP, Cyp4g1 RNAi) or Desat1 RNAi (PromE ^TS > mGFP, Desat1 RNAi). Oenocytes and nuclei are marked with mCD8::GFP (green) and DAPI (blue), respectively. Scale bar = 100 μm. In this and subsequent figures, PromE ^TS driven expression was restricted to adulthood (Methods section)