Table 2.

Average activity over the weekend for children with mitochondrial disease compared to age- and sex-matched controls (including subgroup analyses for ambulatory and non-ambulatory patients and patients with myopathy or encephalopathy. We excluded a boy who was not able to walk but had excellent abilities to move (on his buttock), but not to walk, from the ambulatory/non-ambulatory analyses since we could not define in which group he belonged)

	Patients (n = 17)		Healthy controls (n = 15)			Ambulatory patients (n = 9)			Non ambulatory patients (n = 7)				Myopathy (n = 7)		Enchephalomyopathy (n = 10)
	Median	Range	Median	Range	p-value for difference between patients and healthy controls	Median	Range	p-value for difference between ambulatory patients and healthy controls	Median	Range	p-value for difference between non-ambulatory patients and healthy controls	p-value for difference between ambulatory and non-ambulatory patients	Median	Range	Median	Range	p-value for difference between patients with myopathy and patients with encephalomyopathy
Wear time (h/day)	10	(8–13)	12	(6–15)	0.004	12	(9–14)	0.04	11	(9–12)	0.2	0.5	11	(8–13)	10	(8–12)	0.3
Average % rest	86	(44–99)	60	(2–89)	<0.001	73	(44–90)	0.2	98	(86–99)	0.003	0.006	77	(63–99)	89	(44–98)	0.6
Average % standing	4	(0–23)	18	(7–48)	0.004	16	(4–23)	0.6	1	(0–3)	0.001	<0.001	10	(0–23)	3	(0–22)	0.8
Average % dynamic activity	13	(1–50)	18	(5–33)	0.02	14	(3–34)	0.2	5	(1–50)	0.3	0.09	13	(1–50)	9	(5–35)	0.4
Average counts upper leg (1,000 counts/h)	9.4	(3.1–29.6)	18.0	(7.0–27.2	0.008	12.7	(8.2–29.6)	0.2	5.5	(3.1–17.4)	0.02	0.03	9.1	(3.1–16.9)	10.0	(5.1–29.6)	0.7
Average counts upper arm (1,000 counts/h)	15.7	(11.3–36.2)	19.0	(10.5–30.2)	0.3	18.9	(14.2–32.2)	0.9	14.3	(11.3–36.2)	0.5	0.1	16.5	(11.3–25.2)	15.5	(13.2–36.2)	0.6
Average counts lower arm (1,000 counts/h)	21.5	(16.1–41.8)	27.1	(15.3–37.1)	0.3	23.3	(18.9–40.3)	0.8	20.0	(16.1–41.8)	0.6	0.1	21.5	(16.1–31.8)	21.2	(17.8–41.8)	0.9
Average counts wheelchair (1,000 counts/h)	1.3	(0.7–1.4)	NA		NA	NA	0.8	NA	1.3	(0.7–1.5)	NA	0.6	NA	1.4	1.2	(0.7–1.5)	0.9
Maximal intensity upper leg (1,000 counts/min)	1.0	(0.5–2.6)	1.9	(0.9–2.6	<0.001	1.3	(0.7–2.6)	0.09	0.9	(0.5–1.0)	0.006	0.03	0.9	(0.5–1.7)	1.0	(0.9–2.6)	0.6
Maximal intensity upper arm (1,000 counts/min)	1.0	(0.8–1.9)	1.6	(0.9–2.1)	<0.001	1.1	(0.8–1.9)	0.08	0.9	(0.8–1.2)	0.008	0.06	1.0	(0.9–1.4)	1.0	(0.8–1.9)	0.8
Maximal intensity lower arm (1,000 counts/min)	1.2	(0.9–2.2)	1.9	(1.0–2.5)	<0.001	1.4	(1.0–2.2)	0.09	1.1	(0.9–1.4)	0.009	0.09	1.2	(1.0–1.8)	1.2	(0.9–2.2)	0.9
Largest AUC during 1/2 h upper leg (1,000 counts)	10.4	(6.4–37.3)	26.8	(11.4–66.2)	<0.001	20.2	(8.9–37.2)	0.02	9.9	(6.4–17.3)	0.006	0.03	9.5	(6.4–37.3)	13.9	(7.4–30.7)	0.4
Largest AUC during 1/2 h upper arm (1,000 counts)	15.8	(1.1–27.3)	25.3	(11.7–368)	0.003	17.9	(14.0–27.3)	0.07	14.6	(11.1–25.1)	0.03	0.09	15.5	(11.1–27.3)	17.0	(11.9–25.1)	0.5
Largest AUC during 1/2 h lower arm (1,000 counts)	21.2	(16.0–34.8)	30.8	(16.7–43.4)	0.004	25.6	(18.5–34.8)	0.05	18.2	(16.0–29.3)	0.2	0.04	20.4	(16.0–34.8)	22.9	(16.7–29.9)	0.5

A level of p = 0.05 was used for significance; significant values are indicated in bold

AUC area under the curve, min minutes