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. 2017 Nov 9;7:15208. doi: 10.1038/s41598-017-15207-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Construction of PPE infusion experimental AAA in rats and the expression of PI3K and pAKT in aneurismal aorta. 8–12 week-old male Sprague-Dawley rats were employed for PPE-induced AAA model. Vernier caliper was employed to measure the diameter of aorta directly underwent laparotomy at day 0 and day 28 after PPE infusion. An AAA was defined as a 50% increase in aortic diameter compared with baseline. (A) Representative images of aorta and H&E staining from PPE-infused rats and PBS-infusion rats at day 28. (B) Aortic diameter at day 0 and day 28 after PPE infusion (n = 9) or PBS infusion (n = 10) was measured, Data show mean ± SD and two way ANOVA test, *P < 0.05. (C) Aortic sections from rats 28 days after PPE or PBS infusion were collected and immunoassayed with an antibody against PI3K or pAKT, the representative aortic histology images for PI3K and pAKT staining was shown in LPF (50×) and HPF (200×) respectively. (D) Numbers of positive immunoassayed cells were compared between PPE infusion rats and PBS infusion rats. Data present as mean and SD per HPF. n = 9–10 in each group. Nonparametric Mann-Whitney test. *P < 0.05 vs PBS group. LPF, Low-power field; HPF, High-power field.