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. 2017 Nov 9;7:15208. doi: 10.1038/s41598-017-15207-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PI3K inhibitor treatment inhibits AAA formation and progression. Male SD rats were administrated with intraperitoneal injection of Wortmannin at a dose of 0.5 mg/kg/day (dissolved in DMSO) from day 0 to day 28 after PPE infusion. AAAs diameter for each rat was measured directly underwent laparotomy. (A) Representative images of aorta from Wortmannin treatment or Vehicle treatment in rats at day 0 and day 28. (B) Aortic diameters in rats after PPE infusion treated with Wortmannin (n = 12) or Vehicle (n = 9), ANOVA followed by Newman-Keuls post-test, *P < 0.05 and ** P < 0.01 vs vehicle group. (C) The incidence of AAA in PPE-infused rats with Wortmannin or Vehicle treatment was evaluated. Kaplan-Meier analysis. *P < 0.05 vs vehicle group. (D,E) Histological staining of EVG or Masson was performed to evaluate the development of AAAs. Representative aortic histology images for elastin and SMCs in each group. Medial elastin fragmentation and SMCs destruction were scored as mild 1 to severe 5 using a histology grading system. Data are presented with Mean and SD, n = 9–12 in each group. Nonparametric Mann-Whitney test. * P < 0.05 vs vehicle group.