Fig. 2.

Dependence of bulk solution number density with different solvent–cosolvent mixing ratios. Main panel presents ρ _total for the generic model as a function of cosolvent mole fraction x _c. The line is drawn based on Eq. (3), with ρ _total = 1/v. In the inset, we show a simulation snapshot of the generic system presenting bulk solution for a x _c = 0.5 mixture. The generic parameters for the bulk solution are chosen such that the density dip observed in generic model closely resembles aqueous methanol mixture, see Supplementary Fig. 1