Fig. 4.

Increased gabazine (GBZ)-sensitive tonic current in DMV cells from STZ-treated mice. A: representative traces of GBZ-sensitive (1 µM) tonic currents in neurons from saline (top)- and STZ-treated mice (bottom). Dashed lines represent baseline holding current. B: a significant mean increase in GBZ-sensitive tonic current density was detected in neurons from STZ-treated mice (n = 9) relative to controls (n = 8). *P < 0.05 (unpaired 2-tailed t-test. Overlaid individual neuronal responses are also shown. C: sIPSC frequency in DMV neurons was reduced by >90% in the presence of GBZ. Recording solutions contained kynurenic acid (1 mM) and nipecotic acid (1 mM).