Table 5.
Frequencies of toxic death by trial
| Stages 1–3/4S/4 aged <18 mo | Stage 4 aged ≥18 mo | |||||||
|---|---|---|---|---|---|---|---|---|
| By toxicity | By toxicity and tumor | By toxicity | By toxicity and tumor | |||||
| n/N | % | n/N | % | n/N | % | n/N | % | |
| NB79 | 10/115 | 8.8 | 1/115 | 0.9 | 5/73 | 6.8 | 2/73 | 2.7 |
| NB82 | 4/145 | 2.8 | 5/145 | 3.4 | 5/70 | 7.1 | 3/70 | 4.3 |
| NB85 | 8/276 | 2.9 | 2/276 | 0.7 | 15/129 | 11.6 | 1/129 | 0.8 |
| NB90 | 25/639 | 3.9 | 6/639 | 0.9 | 20/294 | 6.8 | 7/294 | 2.4 |
| NB97 | 13/919 | 1.4 | 3/919 | 0.3 | 15/281 | 5.3 | 5/281 | 1.8 |
| NB2004 | 12/1091 | 1.1 | 4/1091 | 0.4 | 16/425 | 3.8 | 7/425 | 1.6 |
| All | 72/3185 | 2.3 | 21/3181 | 0.7 | 76/1272 | 6.0 | 25/1272 | 2.0 |
| Cochrane–Armitage | P = 0.010 | P = 0.001 | ||||||