Table 2a. Hazard ratios (95% CIs) of cancer across quartiles of serum albumin.

		Quartile 1	Quartile 2	Quartile 3	Quartile 4
	Mediana	42.0	45.0	47.0	50.0	Ptrend
Breast cancer	n cases	197	160	174	72
Model 1		Ref.	0.96 (0.74, 1.24)	0.71 (0.56, 0.91)	0.66 (0.48, 0.91)	0.0002
Model 2		Ref.	1.00 (0.76, 1.32)	0.78 (0.60, 1.01)	0.71 (0.51, 0.99)	0.004
Prostate cancer	n cases	183	156	117	86
Model 1		Ref.	0.96 (0.72, 1.27)	0.75 (0.55, 1.01)	0.81 (0.58, 1.13)	0.18
Model 2		Ref.	0.95 (0.71, 1.27)	0.74 (0.54, 1.02)	0.82 (0.58, 1.16)	0.21
Colorectal cancer	n cases	80	69	64	36
Model 1		Ref.	0.98 (0.69, 1.38)	0.81 (0.57, 1.15)	0.80 (0.52, 1.22)	0.11
Model 2		Ref.	0.98 (0.69, 1.40)	0.81 (0.57, 1.17)	0.84 (0.55, 1.30)	0.18
Lung cancer	n cases	56	53	54	27
Model 1		Ref.	1.06 (0.71, 1.59)	0.99 (0.66, 1.49)	0.79 (0.48, 1.29)	0.26
Model 2		Ref.	1.20 (0.77, 1.88)	1.04 (0.67, 1.63)	0.98 (0.58, 1.65)	0.79
Cancer mortality	n cases	277	177	190	88
Model 1		Ref.	0.77 (0.61, 0.96)	0.73 (0.59, 0.91)	0.60 (0.45, 0.79)	<0.0001
Model 2		Ref.	0.80 (0.63, 1.02)	0.73 (0.58, 0.92)	0.64 (0.48, 0.86)	<0.0001

Abbreviations: BMI=body mass index; CI=confidence interval.

^aMedian concentrations in the subcohort g l⁻¹.

Results from Cox proportional hazards regression analyses.

Model 1 adjusted for age and, where applicable, sex; Model 2 adjusted for age, smoking (never, former, current), lifetime alcohol intake (g per day), current aspirin use (yes/no), physical activity (Cambridge index), waist circumference (cm), BMI (continuous), height (cm), education level (primary school, secondary school, university degree); analyses on breast cancer risk were additionally adjusted for: menopausal status, current hormone therapy use (yes/no), current oral contraceptive use (yes/no), at least one full term pregnancy (yes/no); analyses on colorectal cancer risk were additionally adjusted for: sex, fibre intake (g per day), processed meat intake (g per day).