Table 2c. Hazard ratios (95% CIs) of cancer across quartiles of serum uric acid.

		Quartile 1	Quartile 2	Quartile 3	Quartile 4
	Mediana	0.24	0.32	0.36	0.42	Ptrend
Breast cancer	n cases	165	136	165	111
Model 1		Ref.	0.75 (0.57, 0.99)	0.81 (0.62, 1.06)	0.70 (0.52, 0.93)	0.01
Model 2		Ref.	0.77 (0.57, 1.02)	0.87 (0.66, 1.16)	0.72 (0.53, 0.99)	0.043
Prostate cancer	n cases	145	123	127	120
Model 1		Ref.	0.99 (0.73, 1.35)	1.03 (0.75, 1.40)	0.98 (0.72, 1.33)	0.85
Model 2		Ref.	1.00 (0.72, 1.38)	1.06 (0.76, 1.47)	1.03 (0.74, 1.44)	0.94
Colorectal cancer	n cases	56	54	62	63
Model 1		Ref.	1.01 (0.68, 1.50)	1.05 (0.71, 1.56)	1.14 (0.77, 1.67)	0.78
Model 2		Ref.	0.95 (0.63, 1.43)	1.00 (0.67, 1.50)	0.96 (0.64, 1.46)	0.54
Lung cancer	n cases	39	40	52	49
Model 1		Ref.	1.14 (0.72, 1.81)	1.44 (0.93, 2.23)	1.42 (0.91, 2.23)	0.13
Model 2		Ref.	1.07 (0.65, 1.76)	1.27 (0.79, 2.05)	1.02 (0.62, 1.69)	0.14
Cancer mortality	n cases	200	143	186	174
Model 1		Ref.	0.73 (0.57, 0.94)	0.88 (0.69, 1.11)	0.87 (0.68, 1.11)	0.16
Model 2		Ref.	0.69 (0.53, 0.90)	0.84 (0.65, 1.08)	0.75 (0.58, 0.98)	0.09

Abbreviations: BMI=body mass index; CI=confidence interval.

^aMedian concentrations in the subcohort mg dl⁻¹.

Results from Cox proportional hazards regression analyses.

Model 1 adjusted for age and, where applicable, sex.

Model 2 adjusted for age, smoking (never, former, current), lifetime alcohol intake (g per day), current aspirin use (yes/no), physical activity (Cambridge index), waist circumference (cm), BMI (continuous), height (cm), education level (primary school, secondary school, university degree); analyses on breast cancer risk were additionally adjusted for: menopausal status, current hormone therapy use (yes/no), current oral contraceptive use (yes/no), at least one full term pregnancy (yes/no); analyses on colorectal cancer risk were additionally adjusted for: sex, fibre intake (g per day), processed meat intake (g per day).