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. 2017 Sep 14;117(10):1495–1506. doi: 10.1038/bjc.2017.317

Figure 2.

Figure 2

Effect of stable knockdown of NFE2L2 on chemotherapeutic drug-induced cytotoxicity in HepG2 cells. EPI=epirubicin; 5-FU=fluorouracil; NFE2L2-KD=stable knockdown of NFE2L2; Scramble=scrambled non-target negative control; Veh=Vehicle. (A) mRNA expression of NFE2L2. n=3. *P<0.05 vs Scramble. Cell viability was assessed by MTS assay following 24 h of treatment with indicated concentrations of As2O3 (B), 5-FU (C) and EPI (D); n=6. *P<0.05 vs Scramble with the same treatment.