Table 4. Prognostic impact of mrTRG in specific pTRG patient subgroups.

Outcome measure	pTRG/mrTRG subgroup	n Events/n subjects	5-year survival (95% CI)	Hazard ratio (95% CI)	P value	Pairwise p value
RFS	1. pTRG 0–1/mrTRG 3–5	23/49	57.1 (43.2–71.0)	1.0	(0.023)	1 vs 2
	2. pTRG 0–1/mrTRG 1–2	6/16	73.3 (50.9–95.6)	0.64 (0.26–1.60)	0.34	0.391
	3. pTRG 2/mrTRG 3–5	11/31	65.9 (48.7–83.1)	0.85 (0.41–1.76)	0.65	3 vs 4
	4. pTRG 2/mrTRG 1–2	6/27	76.9 (60.6–93.2)	0.45 (0.18–1.11)	0.081	0.180
	5. pTRG 3–4/mrTRG 3–5	3/24	87.3 (73.8–100)	0.25 (0.07–0.84)	0.025	5 vs 6
	6. pTRG 3–4/mrTRG 1–2	8/44	88.5 (78.9–98.1)	0.30 (0.14–0.68)	0.004	0.974
OS	1. pTRG 0–1/mrTRG 3–5	21/49	63.1 (49.6–76.6)	1.0	(0.053)	1 vs 2
	2. pTRG 0–1/mrTRG 1–2	5/16	80.0 (59.8–100)	0.57 (0.21–1.52)	0.260	0.301
	3. pTRG 2/mrTRG 3–5	10/31	68.8 (51.7–85.9)	0.83 (0.39–1.80)	0.638	3 vs 4
	4. pTRG 2/mrTRG 1–2	5/27	80.6 (65.3–95.9)	0.45 (0.17–1.20)	0.110	0.220
	5. pTRG 3–4/mrTRG 3–5	3/24	91.7 (78.2–100)	0.30 (0.09–1.00)	0.050	5 vs 6
	6. pTRG 3–4/mrTRG 1–2	7/44	90.7 (82.1–99.3)	0.31 (0.013–0.72)	0.007	0.771

Abbreviations: CI=confidence interval; mrTRG=magnetic resonance tumour regression grade; OS=overall survival; pTRG=pathological tumour regression grade; RFS=recurrence-free survival.