Table 3. Estimates of changes from baseline (T1) in major variables and their effect size among IG and CG at T2, T3, and T4.

	2-month change				6-month change				12-month change
Variable	IG (N=107)	CG (N=104)	ES	P	IG (N=105)	CG (N=102)	ES	P	IG (N=96)	CG (N=93)	ES	P
AN	1.12	2.30	0.39	0.0226	0.35	2.92	0.82	<0.0001	−0.33	2.21	0.85	<0.0001
DE	0.63	2.62	0.58	0.0024	−0.74	2.20	0.87	<0.0001	−1.40	1.58	0.95	<0.0001
QOL	−2.83	−9.35	−0.35	0.0005	−1.88	−12.26	−0.58	<0.0001	−5.13	−15.02	−0.55	<0.0001
PF	0.55	−9.85	−0.45	0.0173	−2.33	−13.64	−0.52	0.0024	−5.21	−15.87	−0.47	0.0154
EF	6.63	−6.16	−0.82	0.0001	5.56	−8.41	−0.91	<0.0001	7.54	−5.30	−0.92	<0.0001
RF	2.94	−6.20	−0.69	0.0008	4.95	−7.28	−0.94	<0.0001	5.26	−7.16	−0.94	<0.0001
CF	3.25	−3.49	−0.41	0.0008	4.88	−7.38	−0.82	<0.0001	3.38	−6.11	−0.63	<0.0001
SF	5.74	−2.03	−0.53	0.0226	10.03	−2.38	−0.82	0.0001	12.15	−0.21	−0.91	<0.0001
PA	−2.24	5.21	0.37	0.0018	−3.87	7.34	0.54	<0.0001	−2.21	8.97	0.56	0.0001
FA	−2.39	3.48	0.36	0.0004	−0.95	9.02	0.60	<0.0001	1.64	9.68	0.47	0.0004
NV	6.67	13.89	0.65	0.0295	7.40	16.37	0.79	0.0032	5.63	15.02	0.92	0.0006
IN	−8.00	1.96	0.41	0.0555	−11.59	4.21	0.60	0.0025	−12.97	2.93	0.62	0.0026
AL	−3.28	2.92	0.29	0.0311	−5.07	5.80	0.53	0.0002	−4.13	6.95	0.57	0.0002
RE	1.56	−0.45	−0.31	0.0226	3.95	−0.27	−0.68	<0.0001	4.68	0.38	−0.67	<0.0001
ALI	−0.22	0.49	0.45	0.1345	−0.46	0.67	0.75	0.0009	−0.64	0.78	0.90	<0.0001

Abbreviations: AL=appetite loss; ALI=Allostatic Load Index; AN=anxiety; CF=cognitive function; DE=depression; EF=emotional function; ES=effect size; FA=fatigue; IN=insomnia; NV=nausea and vomit; PA=pain; PF=physical function; QOL=quality of life; RE=resilience; RF=role function; SF=social function.

Notes: a positive (negative) sign for the ES implies that the T2, T3, or T4 adjusted mean for Major Variables was lower (higher) for IG than CG.