Figure 1.

(a) Effects of genetic blockade of A_2AR in the levels of IL-1β and TNF in the retina subjected to transient ischemia. A_2AR-KO mice were subjected to ischemic injury. The protein levels of IL-1β and TNF were quantified by ELISA at 7 days of reperfusion. Results are expressed as the ratio of ischemic eye compared with contralateral eye. *P<0.05, significantly different from contralateral eye, Wilcoxon Signed-Rank test; ^##P<0.01 significantly different from vehicle-treated animals, Student’s t-test. (b) Effects of treatment with KW6002 in the protein levels of IL-1β and TNF upon transient ischemia. KW6002 (3 mg/kg) was administered by oral gavage 2 h post injury and until the end of experiment (7 days of reperfusion). The levels of IL-1β and TNF were quantified by ELISA. Results are expressed as the ratio of ischemic eye compared with contralateral eye. *P<0.05, significantly different from contralateral eye, Wilcoxon's signed-rank test; ^#P<0.05 significantly different from vehicle-treated animals, Student’s t-test