Table 3.
GO: Biological process classification of genes within the NOTCH, BCR, and cell-cycle–signaling cascades in cGVHD B cells after NOTCH2 blockade
| Pathway | Gene identifier | Name/Aliases |
|---|---|---|
| Notch signaling | HES4 | Hes family BHLH transcription factor 4 |
| MMP9* | Matrix metalloproteinase 9 | |
| DUSP1* | Dual-specificity phosphatase 1 | |
| TNFSF12* | Tumor necrosis factor superfamily member 12; TWEAK | |
| BIRC5† | Baculoviral IAP repeat containing 5 | |
| IL6R | Interleukin 6 receptor; CD126 antigen | |
| BCR signaling | FOS*† | Cellular oncogene C-Fos |
| CR2 | Complement component 3d receptor 2; CD21 antigen | |
| FCRL4 | Fc receptor-like 4; IRTA1 | |
| PSTPIP1* | Proline-serine-threonine phosphatase-interacting protein 1 | |
| CDC25A† | Cell division cycle 25A | |
| Cell cycle | FOS*† | Cellular oncogene C-Fos |
| DTL | Denticleless E3 ubiquitin protein ligase homolog | |
| CDC6 | Cell division cycle 6 | |
| SLC19A1 | Solute carrier family 19 member 1 | |
| BIRC5† | Baculoviral IAP repeat containing 5 | |
| CDC25A† | Cell division cycle 25A | |
| MYBL2 | MYB proto-oncogene–like 2 | |
| TTLL12 | Tubulin tyrosine ligase–like 12 | |
| SKA3 | Spindle and kinetochore–associated complex subunit 3 | |
| ORC6 | Origin recognition complex subunit 6 | |
| UBE2C | Ubiquitin-conjugating enzyme E2 C |
BHLH, basic helix loop helix; IAP, inhibitor of apoptosis.
Genes shown in bold are downregulated by NOTCH2 blockade.
*
Genes upregulated by NOTCH2 blockade.
†
Genes categorized into >1 signaling pathway.