Figure 4.

Searching for synergy in CTCL cell lines. (A-D) Four CTCL cell lines were tested for synergy between venetoclax and vorinostat, and between venetoclax and romidepsin. Cell lines were first incubated with incremental increase of each of the 3 drugs individually to calculate IC₅₀ values. Next, cell lines were incubated with combinations of each drug in an approximate 1:1 ratio of the calculated IC₅₀ values. Synergy was noted between venetoclax and vorinostat in the MyLa cell line and between venetoclax and with high doses of romidepsin in the HH cell line.