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. 2017 Nov 9;19:87. doi: 10.1186/s12968-017-0402-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Patient selection flow chart. From 2005 to 2014 a total of 1.181 AL patients visited our institution. Patients had to be excluded for negative or absent cardiac biopsy (Bx), absent CMR examination, or CMR performed after induction of chemotherapy (CHT). The final study cohort consists of 68 AL patients. b Late gadolinium enhancement (LGE) quantification by semiautomatic 5 SD-threshold selection. Contours for endo- (red) and epicardial borders (green) as well as for unenhanced reference myocardium (blue) were drawn manually. Signal intensities above 5-fold standard deviation of the reference myocardium were accounted to the LGE volume in relation to unenhanced myocardium (relative LGE, orange)