Table 2.
Univariate Cox-regression for overall survival or heart transplantation (n = 68)
| Variable | X2 | HR | 95% CI | p |
|---|---|---|---|---|
| NYHA class | 7.5 | 1.75 | 1.15 to 2.68 | 0.001 |
| Karnofsky Index | 21.3 | 0.91 | 0.88 to 0.95 | 0.0001 |
| CMR parameters | ||||
| AAPSE (mm) | 15.6 | 0.10 | 0.03 to 0.34 | 0.0002 |
| MAPSE anterior (mm) | 8.1 | 0.19 | 0.06 to 0.60 | 0.004 |
| MAPSE anterolateral (mm) | 11.7 | 0.23 | 0.10 to 0.56 | 0.001 |
| MAPSE inferolateral (mm) | 6.2 | 0.36 | 0.16 to 0.83 | 0.02 |
| MAPSE inferior (mm) | 9.0 | 0.26 | 0.10 to 0.63 | 0.003 |
| MAPSE inferoseptal (mm) | 7.7 | 0.26 | 0.10 to 0.68 | 0.01 |
| TAPSE (mm) | 6.7 | 0.94 | 0.90 to 0.99 | 0.01 |
| GLS (%) | 11.7 | 1.12 | 1.05 to 1.19 | 0.0006 |
| LSbasal (%) | 8.3 | 1.08 | 1.02 to 1.13 | 0.006 |
| LSmid (%) | 12.8 | 1.13 | 1.06 to 1.21 | 0.0005 |
| LSapical (%) | 6.9 | 1.07 | 1.02 to 1.12 | 0.005 |
| Ejection Fraction (%) | 11.6 | 0.95 | 0.93 to 0.98 | 0.0007 |
| Septal wall (mm) | 0.7 | 1.03 | 0.96 to 1.11 | n.s. |
| Relative LV Mass (g/m2) | 1.8 | 1.01 | 0.99 to 1.02 | n.s. |
| LA dilation a | 0.02 | 1.05 | 0.55 to 1.97 | n.s. |
| Relative LGE (%) | 4.4 | 1.02 | 1.00 to 1.04 | 0.03 |
| Qualitative LGE (n) | 6.8 | 1.50 | 1.09 to 2.06 | 0.009 |
| Laboratory data | ||||
| cTNT ULN a | 5.3 | 1.94 | 1.09 to 3.45 | 0.02 |
| log NT-proBNP (pg/mL) | 13.0 | 1.52 | 1.20 to 1.94 | 0.0006 |
| MDRD (mL/min/1.73m2) | 0.2 | 1.00 | 0.99 to 1.01 | n.s. |
| log FLC difference (mg/dL) | 6.3 | 1.71 | 1.10 to 2.65 | 0.02 |
X 2 chi square, HR hazard ratio, CI confidence interval, adichotomous variable
AAPSE anterior aortic plane systolic excursion, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, GLS global longitudinal strain, LS basal mean longitudinal strain of basal segments 1-6, LS mid mean longitudinal strain of midventricular segments 7-12, LS apical mean longitudinal strain of apical segments 13-16, LA left atrium, relative LGE proportion of late gadolinium enhancement quantified by 5SD method, qualitative LGE late gadolinium enhancement graduated in (1) none, (2) subendocardial or (3) transmural involvement, cTNT ULN cardiac troponin T upper limit of normal, NT-proBNP N-terminal prohormone of brain natriuretic peptide, MDRD glomerular filtration rate calculated with the formula of “Modification of Diet in Renal Disease”, FLC free light chain difference